Sickle$-$cell disease as a model

Select all the reasons why sickle$-$cell disease is a good model for studying how genetic diseases are inherited.

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Sickle$-$cell disease is influenced little by the environment.Sickle$-$cell disease is influenced little by the environment.

Sickle$-$cell disease is a sex$-$linked trait, meaning that it is carried on the X chromosome, and males are more likely to be affected.Sickle$-$cell disease is a sex$-$linked trait, meaning that it is carried on the X chromosome, and males are more likely to be affected.

A single change in a gene results in an identifiable physical characteristic.A single change in a gene results in an identifiable physical characteristic.

Sickle$-$cell disease has an evolutionary significance because carriers of the trait are resistant to some forms of malaria.Sickle$-$cell disease has an evolutionary significance because carriers of the trait are resistant to some forms of malaria.

Sickle$-$cell disease can result from mutations in over $150$ known genes.Sickle$-$cell disease can result from mutations in over $150$ known genes.

The formation of mutated hemoglobin is not influenced by the byproducts of other genes.