Sickle-cell disease is the result of a single nucleotide substitution that replaces Glu with a Val....

 

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Sickle-cell disease is the result of a single nucleotide substitution that replaces Glu with a Val. in the beta chain of hemoglobin. This is best described as a: nonsense mutation splice-site mutation missense mutation framshift mutation Sickle-cell disease is the result of a single nucleotide substitution that replaces Glu with a Val. in the beta chain of hemoglobin. This is best described as a: nonsense mutation splice-site mutation missense mutation framshift mutation