SOLVE

Question A type of antigen-presenting cell that plays a crucial role in activating T cells and initiating immune responses (2). A process in which an HSC divides into two daughter cells with distinct fales or properties (2). A protein complex involved in transporting peptides from the cytoplasm into the endoplasmic reticulum for loading onto MHC class I molecules. A group of proteins that forms pores in the membranes of target cells, leading to cell lysis (3). A type of T cell that directly kills infected or cancerous cells. A type of immune cell that helps regulate immune responses by secreting cytokines and interacting with other immune cells (3). A steroid that connects the neuroendocrine and immune systems A cytokines that enhances NK function A cytokines produced by activated T cells and NK cells, important for antiviral and antitumour responses (2) 10 The requirement that T cells recognise antigen peptides presented on MHC molecules (2). A protein involved in detecting cylosolic DNA and triggering antiviral responses. 12 A family of pattern recognition receptors that detect viral RNA and activate antiviral responses. A multiprotein complex that activates caspases and promotes inflammation in response to cellular stress or infection. The process by which immune cells exit blood vessels and enter tissues during inflammation. 15 A monoclonal antibody used to treat certain inflammatory conditions, including Castleman disease The process by which specific lymphocytes are chosen for survival and proliferation during lymphocyte maturation (2). The genetic process that generates diverse antigen receptor genes in B and T cells (2). Cells that carry out immune responses, such as cytotoxic T cells and plasma cells (2). The antigen receptor on the surface of T cells, responsible for recognising peptide-MHC complexes (3). The antigen receptor on the surface of B cells, involved in antibody production (3) 21 A group of cell surface proteins that present intracellular antigens to cytotoxic T cells (3). Cell surface proteins that present extracellular antigens to helper T cells (3). 23 The variability in antigen receptor genes resulting from the random insertion of nucleotides when joining of gene segments during B and T cell development (2). 24 The enzyme complex responsible for reamanging gene segments during somatic recombination (2). The part of the antigen receptor that directly interacts with antigens (2) The phenomenon where each B cell expresses only one allele of its immunoglobulin genes (2) The process by which immature lymphocytes develop into functional immune cells (2). Cyclooxygenase inhibitor A drug that stimulates the production of neutrophils, commonly used after chemotherapy . A biologic drug used to treat autoimmune diseases by inhibiting tumour necrosis factor Small, bean-shaped structures that filter lymph and house immune cells (2). The first signal required for T cell activation, usually provided by antigen presentation (2). Additional signals (e.g., costimulation) needed for full T cell activation (2). Antigens derived from within the cell, presented by MHC class I molecules (2) Conserved molecular structures on microbes recognised by the innate immune system. Lipid molecules involved in inflammation, pain, and fever. A viral neuraminidase inhibitor 38 The process by which immune cells engulf and digest pathogens An enzyme that breaks down hydrogen peroxide in cells, used by Staphylococcus to evade the immune system