Question: Succinate is accumulated when the _ _ _ _ _ _ _ _ _ _ _ _ fails to convert it to fumarate. Succinate then

Succinate is accumulated when the ____________ fails to convert it to fumarate. Succinate then spillovers from the _____________- to the cytoplasm. The outcome of the spillover is inhibition of the enzyme responsible to hydroxylate HIF-1 to the proteasome. HIF-1 activates the ____________________ resulting in glycolysis activation due to inhibition of Acetyl CoA formation
Fumarase dehydrogenase; mitochondrial matrix; pyruvate dehydrogenase kinase
Succinate dehydrogenase; mitochondrial inner membrane; pyruvate dehydrogenase kinase
Succinate dehydrogenase; mitochondrial matrix; pyruvate dehydrogenase kinase
Succinate dehydrogenase; mitochondrial matrix; pyruvate dehydrogenase phosphatase
Succinate dehydrogenase; mitochondrial intermembrane space; pyruvate dehydrogenase kinase

Step by Step Solution

There are 3 Steps involved in it

1 Expert Approved Answer
Step: 1 Unlock blur-text-image
Question Has Been Solved by an Expert!

Get step-by-step solutions from verified subject matter experts

Step: 2 Unlock
Step: 3 Unlock

Students Have Also Explored These Related Biology Questions!

Q:

QUESTION THREE [25] 3.1 Cassava Ltd, operates in the farming industry. They feel that some of their older gas welding machines need to be replaced. The company's present capital structure is as...

Q:

Succinate dehydrogenase (SDH) is an enzyme involved in aerobic respiration that converts succinate into fumarate. SDH activity is thought to be reduced during periods of hypoxia (lower than normal...

Q:

Certain microorganisms with a modified citric acid cycle decarboxylate a -ketoglutarate to produce succinate semi-aldehyde: (a) Succinate semialdehyde is then converted to succinate, which is further...

Q:

1. Rat liver mitochondria (3 mg were suspended in a Clark Oxygen Electrode chamber in ionic medium (100 mM KCI, 5 mM HEPES-KOH pH 7.0, 2 mm MgCl2) then the lid was placed on the chamber. Oxygen...

Q:

The allosterically regulated enzyme ATCase binds aspartic acid as a substrate and acylates the a -amino group. Succinate acts as a competitive inhibitor of ATCase because it binds the active site but...

Q:

All the dehydrogenases of glycolysis and the citric acid cycle NAD + as electron acceptor except succinate dehydrogenase, which uses covalently bound FAD. The E value for fumarate / succinate is 0 ....

Q:

just the answers please thanks in advance!!! Considering the energy changes associated with the individual reactions below, which reaction can be coupled with the hydrolysis of ATP to generate a...

Q:

9. [6 marks] The graph below shows a Lineweaver-Burke plot for an enzyme reaction in which the inhibitor is succinate. The equation for the line is given below: (a) From this equation, state the...

Q:

Reactions in complex II. Use of FAD instead of NAD + in the oxidation of succinate. All dehydrogenases from glycolysis and the citric acid cycle use NAD + (E for NAD + / NADH is 0.32V) as the...

Q:

14.6 Complex II Complex II is succinatorubiquinone oxidoreductase, and is also called the succinate dehydrogenase complex. It is the same enzyme as the one mentioned in the previous chapter (section...

Q:

For the half-reaction FAD + 2 e- + 2 H+ FADH2 E 0.00 V for FAD bound to succinate dehydrogenase. (a) Calculate G for the oxidation of succinate to fumarate by enzyme-bound FAD. (b) How does this...

Q:

Recall the definition of a linear predictor. Define (h) as the best linear predictor of xt+h given Xt, ...,X+h-1 (the best linear predictor is the one with the smallest expected squared error)....

Q:

Consider the following "greedy" strategy for the rod cutting problem: define the density of a rod of length i to be p/i, that is, its value per inch. The greedy strategy for a rod of length n cuts...

Q:

3 8 TB MC Qu . 0 5 - 7 5 Which of the following is most likely to . . . Which of the following is most likely to be considered an analytical procedure? 3 points 0 1 : 5 7 : 4 5 Multiple Choice...

Q:

hi, can you please help answer this question: Siegfried Basset is 65 years of age and has a life expectancy of 12 more years. He wishes to invest $20,000 in an annuity that will make a level payment...