For the half reaction FAD 2 e 2 H FADH2 E 0 00 V for FAD bound to succinate dehydrogenase (a) Calculate G for the oxidation of succinate to fumarate by enzyme bound FAD (b) How does this compare to the G for the oxidation of succinate to fumarate by free NAD (c) Based on these results, explain why nature chose FAD rather than NAD as the oxidizing agent in the succinate dehydrogenase reaction

Question: For the half-reaction FAD + 2 e- + 2 H+ FADH2 E 0.00 V for FAD bound to succinate dehydrogenase. (a) Calculate G

For the half-reaction
FAD + 2 e- + 2 H+ ⇆ FADH2
E °′≈ 0.00 V for FAD bound to succinate dehydrogenase.
(a) Calculate ΔG°′ for the oxidation of succinate to fumarate by enzyme-bound FAD.
(b) How does this compare to the ΔG°′ for the oxidation of succinate to fumarate by free NAD+?
(c) Based on these results, explain why nature chose FAD rather than NAD+ as the oxidizing agent in the succinate dehydrogenase reaction.

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