For the half-reaction FAD + 2 e- + 2 H+ FADH2 E 0.00 V for
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FAD + 2 e- + 2 H+ ⇆ FADH2
E °′≈ 0.00 V for FAD bound to succinate dehydrogenase.
(a) Calculate ΔG°′ for the oxidation of succinate to fumarate by enzyme-bound FAD.
(b) How does this compare to the ΔG°′ for the oxidation of succinate to fumarate by free NAD+?
(c) Based on these results, explain why nature chose FAD rather than NAD+ as the oxidizing agent in the succinate dehydrogenase reaction.
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Related Book For
Fundamentals of biochemistry Life at the Molecular Level
ISBN: 978-0470547847
4th edition
Authors: Donald Voet, Judith G. Voet, Charlotte W. Pratt
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