Symptomsofdepressionandanxietycan significantly impact a patient's health status and quality of life. The APPROACH-IS study administered the Hospital Anxiety and Depression Scale (HADS) to assess the prevalence ofdepression and anxiety symptoms among adultswith congenital heart disease and theirpotential impacton health status andquality of life. Thefollowingtablefrom Kovaks, et al.

2023 publication includes the associated score ranges indicating elevated symptoms ofdepressionandanxiety.

Table1.

HADSScore	DepressionandAnxietySymptoms
8-10	Mildlyelevated
11-13	Moderatelyelevated
14orgreater	Severelyelevated

Assume the HADS scores in the study sample are normally distributed with a mean of 5.6 and a standard deviation of 4.75. If 19 study participants complete the HADS, what would be the 99%confidenceintervalaroundthisestimateofthemean?

What isthemarginoferror?

1. 0.720
2. 2.77
3. 3.14
4. 3.20