Tetracycline hydrochloride (Achromycin V, Lederle) is prescribed for a young adult male patient (28 years old,...

 

Transcribed Image Text:

Tetracycline hydrochloride (Achromycin V, Lederle) is prescribed for a young adult male patient (28 years old, 78 kg) suffering from gonorrhea. According to the literature, tetracycline HCI is 77% orally absorbed, is 65% bound to plasma proteins, has an apparent volume of distribution of 0.5 L/kg, has an elimination half-life of 10.6 hr, and is 58% excreted unchanged in the urine. The minimum inhibitory drug concentration (MIC) for gonorrhea is 30 g/mL. a. b. Achromycin V is available in 250-mg and 500-mg capsules. How many capsules (state dose) should the patient take every 6 hours? Calculate an exact maintenance dose for this patient to be given every 6 hours around the clock. Tetracycline hydrochloride (Achromycin V, Lederle) is prescribed for a young adult male patient (28 years old, 78 kg) suffering from gonorrhea. According to the literature, tetracycline HCI is 77% orally absorbed, is 65% bound to plasma proteins, has an apparent volume of distribution of 0.5 L/kg, has an elimination half-life of 10.6 hr, and is 58% excreted unchanged in the urine. The minimum inhibitory drug concentration (MIC) for gonorrhea is 30 g/mL. a. b. Achromycin V is available in 250-mg and 500-mg capsules. How many capsules (state dose) should the patient take every 6 hours? Calculate an exact maintenance dose for this patient to be given every 6 hours around the clock.