The following pharmacokinetic parameters were determined following the oral administration of Drug A: Systemic clearance (CLS) =
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The following pharmacokinetic parameters were determined following the oral administration of Drug A: Systemic clearance (CLS) = 9 L/hr Fraction excreted unchanged (fe) = 0 Bioavailability (F) = 45 % a) Showing all working and stating all assumptions, determine
(i) the proportion of Drug A that is absorbed from the gastrointestinal tract (fg), and
(ii) the proportion of Drug A that escapes first pass metabolism (fh)
Related Book For
Statistics for Business Decision Making and Analysis
ISBN: 978-0321890269
2nd edition
Authors: Robert Stine, Dean Foster
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