The four changes that present challenges in management information systems $($MIS$)$ include the growth of cloud computing, the use of Big Data and the Interne Things $($IoT$),$ the mobile platform, and the application of to help managers understand their business and products.

A$.$ laws and regulations

B$.$ artificial intelligence $($AI$)$

C$.$ local customs and cultures

D$.$ global positioning systems $($GPS$)$

E$.$ digital learning techniques