The Heart and Estrogen Replacement Study was a large scale study designed to examine risk factors for coronary heart disease in a cohort of post-menopausal women. The data contains a number of biomarkers such as serum cholesterol and glucose measurements, anthropometric data such as body mass index (BMI) and waist to hip ratio, and behavioral data such as exercise frequency and smoking status.

In the examples shown below, SAS output 1-5 represent example analyses from this data on N = 2608 individuals. The outcome variable in all cases is high density lipoprotein (HDL) cholesterol at year 1 of the study. In each analysis below, at least one of the following variables are used as explanatory variables:

Physact1 = physical activity level (1=low, 2=moderate, 3=frequent)

Smoking = smoking status (1=smoker, 0=nonsmoker)

TCHOL = total cholesterol (continuous variable)

BMI = body mass index (continuous variable)

Exercise = exercise frequency (1=regular, 0=irregular)

SAS OUTPUT 1 Dependent Variable: HDL1 year 1 HDL cholesterol (mg/dl) The GLM Procedure Least Squares Means Source DF Sum of Squares Mean Square F Value Pr > F Adjustment for Multiple Comparisons: Tukey-Kramer Model A D E G <.0001 physact1 hdl1 lsmean number error f corrected total c in r-square coeff var root mse mean least squares means for effect pr> [t) for HO: LSMean(i)=LSMean(j) Standard Dependent Variable: HDL1 Parameter Estimate Error t Value Pr > It 3 Intercept 49.74806801 8 0.54289412 91.63 1 0.0225 <.0001 physact1 b sas output dependent variable: hdl1 year hdl cholesterol source df sum of squares mean square f value pr> F Standard Model 5568.5601 1113.7120 5.84 <.0001 parameter estimate error t value pr> It Error 2602 496078.2984 190.6527 Intercept 50.09829868 8 0.60033496 83.45 <.0001 corrected total physact1 r-square coeff var root mse hdl1 mean b smoking source df type i ss square f value pr> F 0.07 0.9412 physact1 2 4891.807273 2445.903636 physact1"SMOKING 3 1 0.14499250 B 1.96398691 12.83 <.0001 physact1 b smoking source df type iii ss mean square f value pr> F physact1"SMOKING 1 1 0.00000000 B physact1 2 2340.410047 1170.205024 6.14 0.0022 physact1"SMOKING 1 0 0.00000000 B SMOKING 409.443473 409.443473 2.15 0.1429 physact1" SMOKING 2 246.430781 123.215391 0.65 0.5241