Question: The oxygen (gas) is bubbled through the bioreactor, where it gets dissolved in the aqueous solution and then is subsequently consumed by the cells.
The oxygen (gas) is bubbled through the bioreactor, where it gets dissolved in the aqueous solution and then is subsequently consumed by the cells. The rate at which oxygen gets transferred from gas phase to the liquid (OTR) can be written as OTR ka(Co-Co) Here, OTR : - oxygen transfer rate (units g/L h) ka : - oxygen transfer coefficient, volumetric (units 1/h) Co-saturated concentration of dissolved oxygen (units g/L) Co- concentration of dissolved oxygen in the bioreactor (units g/L) The dissolved oxygen is then consumed by the cells for metabolism. Oxygen consumption by the cells (also called as Oxygen Uptake Rate, OUR) depends upon the cell population. OUR = 90X Here, OUR : - volumetric oxygen uptake rate (units g/L h)
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