The thioester (5)-3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) is reduced by HMG-CoA reductase to form the intermediate mevaldehyde, which is shown in an abbreviated form in the image. Draw the intermediate formed from reaction of mevaldehyele with NADPH and use curved arrows to show electron movement. Be sure to show the R and ' R groups (Located in the Groups menu), charges, and non-bonding electron pairs as needed.

 

Transcribed Image Text:

R₁ NADPH NH₂2 R H Mevaldehyde H₂O* H₂O R₁ NADP' NH₂ R : ÖH H 'H Mevalonate R₁ NADPH NH₂2 R H Mevaldehyde H₂O* H₂O R₁ NADP' NH₂ R : ÖH H 'H Mevalonate

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Reaction H 0 NAD PH H Mechanism WH H 20 R NADPH ... View the full answer