Then calculate temperature change per unit time by considering the bio$-$effect is volume. Use

$\frac{dT}{dt}=\frac{2I}{C_v}$ where

$T=$ Temperature

$t=$ time

$=$ attenuation $=0\mathrm{.}44\frac{dB}{cm}$

$=$ brain tissue density $=1\mathrm{.}03{10}^{3}kg$

$C_v=$ Specific heat Capacit$\frac{y}{m}{m}^3{m}^3$

$=3630$ Joule $=3630\frac{\text{J}\text{o}\text{u}\text{l}\text{e}}{kg*C}($brain$).$