Question: Through directed evolution, enzymes can be designed in laboratories to catalyze new desired reactions. This research idea led to a share of the Nobel Prize

Through directed evolution, enzymes can be designed in laboratories to catalyze new desired reactions. This research idea led to a share of the Nobel Prize in Chemistry to be awarded to Frances Arnold in

2018 .

You have just evolved and isolated an enzyme which can catalyze the following reaction. Draw arrow pushing mechanism to describe the following transformation. Use B: and HA as surrogates for basic

/

acidic amino acid residues.

Through directed evolution, enzymes can be designed in laboratories to catalyze

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