Using 1st order models shown in homework 3 solution determine the probability of coding region in frame two for DNA fragment AGTAGCTTCCAG. Use only parameters provided in the homework solution (Show all of your work.

HW solution:

First order Markov model is described by P(i|j) = P(observing ji in DNA sequence) = nji/nj for the sequence1_A2 is:

P(AA) 0.270462633

P(AC) 0.28113879

P(AG) 0.266903915

P(AT) 0.181494662

P(CA) 0.2

P(CC) 0.263414634

P(CG) 0.392682927

P(CT) 0.143902439

P(GA) 0.202868852

P(GC) 0.325819672

P(GG) 0.350409836

P(GT) 0.118852459

P(TA) 0.116161616

P(TC) 0.323232323

P(TG) 0.409090909

P(TT) 0.151515152