write a discussion response to The inflammatory response is a normal protective mechanism, while autoimmune disorders result from a dysfunctional immune system attacking the body's tissues. Compare and contrast the pathophysiology of acute inflammation versus an autoimmune disorder (e.g., rheumatoid arthritis or lupus). What are the key clinical manifestations of each, and how do treatment approaches differ? Provide an example of how a nurse would assess and manage a patient with each condition. Comparing and contrasting the pathophysiology of acute inflammation versus an autoimmune disorder (e.g., rheumatoid arthritis or lupus). The acute inflammatory response is a natural defense mechanism that the body uses to protect us from things such as infection, injury, and toxins. In response to these situations, the immune system responds rapidly and sends white blood cells to the affected areas. This protective response causes erythema, edema, heat, and pain to those areas. "When cellular or tissue damage occurs, inflammatory mediators are released causing a number of changes in the microcirculation. The ultimate result of these changes is the migration of leukocytes, plasma proteins, and other biochemical mediators from the circulation into the nearby damaged tissue, where they can work together to destroy invaders, limit tissue injury, and promote healing" (Huether et al., 2020, p. 135). In contrast, autoimmune disorders, such as rheumatoid arthritis and lupus, is a result o