Diagnostic Tests: Plasma Volume Total plasma volume is important in determining the required plasma component in blood replacement therapy for a person undergoing surgery. Plasma volume is influenced by the overall health and physical activity of an individual. (Reference: See Problem 21.)

Suppose that a random sample of 45 male firefighters are tested and that they have a plasma volume sample mean of x 5 37.5 ml/kg (milliliters plasma per kilogram body weight). Assume that s 5 7.50 ml/kg for the distribution of blood plasma.

(a) Find a 99% confidence interval for the population mean blood plasma volume in male firefighters.

What is the margin of error?

(b) What conditions are necessary for your calculations?

(c) Interpret your results in the context of this problem.

(d) Sample Size Find the sample size necessary for a 99% confidence level with maximal margin of error E 5 2.50 for the mean plasma volume in male firefighters.

AppendixLO1