Question: Should minimum sample size estimation be based on a one-sided or a two-sided test, assuming the underlying distributions are normal, of (a) a difference in

Should minimum sample size estimation be based on a one-sided or a two-sided test, assuming the underlying distributions are normal, of

(a) a difference in nausea scores between ondansetron hydrochloride and placebo in DB2 and of

(b) the difference between assay types in DB8?

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