Question: Suppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein

Suppose that a G protein undergoes a mutation that allows the exchange of bound GTP for GDP to occur in the absence of G protein binding to a receptor. How might this mutation aﬀect signaling involving a GPCR? Which subunit of the G protein is most likely aﬀected by the mutation?

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