The catalytic efficiency of many enzymes depends on pH. Chymotrypsin shows a maximum value of kcat/KM at

Question:

The catalytic efficiency of many enzymes depends on pH. Chymotrypsin shows a maximum value of kcat/KM at pH 8. Detailed analysis shows that k cat increases rapidly between pH 6 and 7 and remains constant at higher pH. K M increases rapidly between pH 8 and 10. Suggest explanations for these observations.