The drug Eliquis (apixaban) is used to help prevent blood clots in certain patients. In clinical trials, among 5924 patients treated with Eliquis, 153 developed the adverse reaction of nausea (based on data from Bristol-Myers Squibb Co.). Construct a 99% confidence interval for the proportion of adverse reactions.

In each case,

(a) Find the best point estimate of the population proportion p;

(b) Identify the value of the margin of error E;

(c) Construct the confidence interval;

(d) Write a statement that correctly interprets the confidence interval.