Question: The two most general amine syntheses are the reductive amination of carbonyl compounds and the reduction of amides. Show how these techniques can be used

The two most general amine syntheses are the reductive amination of carbonyl compounds and the reduction of amides.
Show how these techniques can be used to accomplish the following syntheses.
(a) benzoic acid → benzylamine
(b) benzaldehyde → benzylamine
(c) pyrrolidine → N-ethylpyrrolidine
(d) cyclohexanone → N-cyclohexylpyrrolidine
(e) HOOC - (CH2)3 - COOH → pentane-1, 5-diamine 1cadaverine2

Step by Step Solution

★★★★★

3.51 Rating (164 Votes )

There are 3 Steps involved in it

1 Expert Approved Answer

Step: 1 Unlock

a b c d e ... View full answer

Question Has Been Solved by an Expert!

Get step-by-step solutions from verified subject matter experts

Step: 2 Unlock

Step: 3 Unlock

Document Format (1 attachment)

893-C-O-O-C (1788).docx

120 KBs Word File

Students Have Also Explored These Related Organic Chemistry Questions!

Amino acids can be synthesized by reductive amination Î±-keto of acids (Section 21.8). Biological organisms can also Î±-keto convert acids into amino acids, but because H2...

Draw the expected product of the following reductive amination: [H,SO,] NABH,CN `NH2

One problem with reductive amination as a method of amine synthesis is that by-products arc sometimes obtained. For example, reductive amination of benzaldehyde with methylamine leads to a mixture of...

4. a. On the next page, draw a mechanism for formation of an amide from an acid anhydride under neutral conditions. b. Why does the second amine and not the carboxylate anion deprotonate the first...

Model 1: Formation of Amides Only acid chlorides and anhydrides can be used to synthesize amides, because they are the only derivatives that are reactive enough for neutral conditions. neutral 2RNH2...

The drug mechktrethamine is used in antitumor therapy. It is one of a family of compounds called nitrogen mustctrds, which also includes the antitumor drugs cyclophosphamide and chlorambucil. (a)...

point 1 If two equivalents of amine react with one equivalent of phosgene, then * : is formed (Urethane 0 (Nitriles 0 (urea 0

If two equivalents of amine react with one equivalent of phosgene. Does it have to be formed? 1_urethanes 2_nitrites 3_urea

assay of what you may think is important and what can be interesting from this reading. Does technology make your life easier? 1.1 Introduction: the "Easier-life Thesis" It is commonly repeated that...

Objective: Demonstrate understanding of Cost Estimation, Cost-Volume-Profit, and Short- term Decision-making Deliverables: 1) Using the data on the "Cost Data" tab of the Template file, a. Create a...

In an experiment on photoelectric effect, the slope of the cut-off voltage versus frequency of incident light is found to be 4.12 10-5 V s. Calculate the value of Planck's constant.

What were the first cash-settled futures contracts and are they still trading today?

1 4 . Assume partnership basis of $ 1 0 K . What are tax conseqences of the following liquidating distributions? a . cash 1 5 K b . cash 2 K , unrealized receivables ( FMV 5 , basis 0 ) c . cash 2 K...

What are the advantages and disadvantages to an individual of having dual citizenship? What are the advantages and disadvantages to a country of allowing dual citizenship?

When 3, 3-dimethyl-2-butanol is treated with concentrated HI, a rearrangement takes place. Which alkyl iodide would you expect from the reaction? (Show the mechanism by which it is formed.)

Write stereochemical formulas for all of the products that you would expect from each of the following reactions. (You may find models helpful.) (a) (b) (c) (d) (1) OsO4 (2) NaHSO3, H2O (1) OsO (2)...

(a) Write a mechanism for the following reaction. (b) What general conditions would you use to ensure a good yield of the product? (c) What general conditions would you use to carry out the reverse...

Bethesda Mining Company reports the following balance sheet information for 2013 and 2014. Required: Prepare the 2013 and 2014 common-size balance sheets for Bethesda Mining. (Do not round...

Please complete the following tables using canadian tax laws It is January 3, 2022. Hayley Stewart, the controller for the Fraser Operating Group, is reviewing the GST compliance requirements for the...

Mining Corp has 9 million shares of common stock outstanding, 350000 shares of preferred stock outstanding with $9 annual stated dividend, and 120000 bonds outstanding with a 10% semiannual coupon...