One problem with reductive amination as a method of amine synthesis is that by-products arc sometimes obtained.
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One problem with reductive amination as a method of amine synthesis is that by-products arc sometimes obtained. For example, reductive amination of benzaldehyde with methylamine leads to a mixture of N-methyl benzyl amine and N-methyldibenzylamine. How do you suppose the tertiary amine byproduct is formed? Propose a mechanism.
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Benzaldehyde first reacts with methylamine and NaBH3CN in the usua...View the full answer
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