The Zeisel method is an analytical procedure for determining the number of methoxyl groups in a compound.

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The Zeisel method is an analytical procedure for determining the number of methoxyl groups in a compound. A weighed amount of the compound is heated with concentrated HI, ether cleavage occurs, and the iodomethane product is distilled off and passed into an alcohol solution of AgNO3, where it reacts to form a precipitate of silver iodide. The AgI is then collected and weighed, and the percentage of methoxyl groups in the sample is thereby determined. For example, 1.06 g of vanillin, the material responsible for the characteristic odor of vanilla, yields 1.60g of AgI. If vanillin has a molecular weight of 152, how many methoxyl groups does it contain?

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