There are many methods for activating a carboxylic acid in preparation for coupling with an amine. The
Question:
(a) Explain why an NHS ester is much more reactive than a simple alkyl ester.
(b) Propose a mechanism for the reaction shown.
(c) Propose a mechanism for the reaction of the NHS ester with an amine, R - NH2.
Transcribed Image Text:
+ F3C O-N O-N он он NHS ester
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a One important factor in ester reactivity is the ability of the alkoxy group to leave and ...View the full answer
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