There is evidence that alkylation at O-4 of thymine, like alkylation at O-6 of guanine, is another

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There is evidence that alkylation at O-4 of thymine, like alkylation at O-6 of guanine, is another mutagenic event that can lead to cancer.
Explain why 04 alkylation at thymine would disrupt Watson-Crick base pairing.
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