Question: Assume that some protein molecule, in its folded native state, has one favored conformation. But when it is denatured, it becomes a random coil, with

Assume that some protein molecule, in its folded native state, has one favored conformation. But when it is denatured, it becomes a "random coil," with many possible conformations.
a. What must be the sign of ∆S for the change: native → denatured?
b. How will the contribution of ∆S for native → denatured aﬀect the favorability of the process? What apparent requirement does this impose on ∆ H if proteins are to be stable structures?

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