Consider the following solid-phase peptide synthesis: (a) Give the structure of each compound A-P. (b) Explain the
Question:
(a) Give the structure of each compound A-P.
(b) Explain the reason for the Boc group on the side chain of the Lys group in the reaction B C
(c) Explain why Boc-Val rather than Fmoc-Val is used in the D E step of the synthesis.
Transcribed Image Text:
solid phase; structure in Eq. 26.21, p. 1285 20% piperidine DMF FmocNHCH2C Cs CICH FmocNHCHCO2H (CH24 NHBoc 20% piperidine Boc-Val E DCC/NHS α-Fmoc-e-Boc-Lys DCC/NHS CFCO2H _encoln, Peptide p
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a Compound A results from the SN2 coupling reaction to the resin analogous to Eq 2622 on text p 1285 ...View the full answer
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