The polymeric resin used for Merrifield solid-phase peptide synthesis (Section 26.8) is prepared by treating polystyrene with N-(hydroxymethyl) phthalimide and trifluoromethanesulfonic acid, followed by reaction with hydrazine. Propose a mechanism for bothsteps.

Transcribed Image Text:

CH2NH2 N-CH-он N. H2NNH2 CH2 CF3SO3H -CH2-CH CH2-CHt Polystyrene -CH2—Cн—