Question: Derive the rate expression for an enzyme-catalyzed unimolecular (single substrate) reaction, such as that shown in steps 9.1 and 9.2, assuming that the decomposition of

Derive the rate expression for an enzyme-catalyzed unimolecular (single substrate) reaction, such as that shown in steps 9.1 and 9.2, assuming that the decomposition of the reactive intermediate to give the product is reversible, rather than irreversible as indicated in step 9.2. Can the initial rate in the forward direction and the initial rate in the reverse direction be expressed in the form of a Michaelis-Menten rate equation? If so how? If not, why?

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