Question: Many enzyme-catalyzed reactions are consistent with a modified version of the Michaelis-Menten mechanism in which the second step is also reversible. (a) For this mechanism

Many enzyme-catalyzed reactions are consistent with a modified version of the Michaelis-Menten mechanism in which the second step is also reversible.
(a) For this mechanism show that the rate of formation of product is given by

Where v max = kd [E]0 v max = k[E]o' KM= (k: + kb)/ka, and KM= (k; + kb)/kb.
(b) Find the limiting behaviour of this expression for large and small concentrations of substrate.

(Vma/KM)(S] (/K[P] 1+ [SJ/K + (P]/K

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a The mechanism considered is ES ES PE k k We apply the steadystate approximation to ES dES dr Subst... View full answer

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