If 10 cases are observed over 1 year among 500 boys 0–4 years of age with smoking mothers, then test whether there is a significant difference in asthma incidence between this group and the general population using the critical-value method with a two-sided test. 

Pulmonary Disease

Suppose the annual incidence of asthma in the general population among children 0–4 years of age is 1.4% for boys and 1% for girls.