# What is the probability that exactly two of the two offspring will be affected in a family

## Question:

What is the probability that exactly two of the two offspring will be affected in a family with dominant disease with reduced penetrance?

**Genetics**

A dominantly inherited genetic disease is identified over several generations of a large family. However, about half the families have dominant disease with complete penetrance, whereby if a parent is affected there is a 50% probability that any one offspring will be affected. Similarly, about half the families have dominant disease with reduced penetrance, whereby if a parent is affected there is a 25% probability that any one offspring will be affected.

Suppose in a particular family one parent and two of the two offspring are affected.

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