# What is the probability that the mode of transmission for this particular family is dominant with complete

## Question:

What is the probability that the mode of transmission for this particular family is dominant with complete penetrance? Is this a prior probability or a posterior probability?

**Genetics**

A dominantly inherited genetic disease is identified over several generations of a large family. However, about half the families have dominant disease with complete penetrance, whereby if a parent is affected there is a 50% probability that any one offspring will be affected. Similarly, about half the families have dominant disease with reduced penetrance, whereby if a parent is affected there is a 25% probability that any one offspring will be affected.

Suppose in a particular family one parent and two of the two offspring are affected.

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