At first glance, it would seem a dangerous strategy for the thymus to actively promote the survival,
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At first glance, it would seem a dangerous strategy for the thymus to actively promote the survival, maturation, and emigration of developing T cells that bind weakly to self peptides bound to self MHC molecules. Would it not be safer to get rid of these T cells, along with those that bind strongly to such self-peptide–MHC complexes, as this would seem a more secure way to avoid autoimmune reactions?
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Related Book For
Molecular Biology Of The Cell
ISBN: 9780815344322
6th Edition
Authors: Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
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