A Hox4 protein is a transcription factor involved in limb development in mammals. Its ability to activate genes required for limb development depends on two functions: its DNA binding and its interaction with the transcription initiation complex.

A mutation occurs in HOX4 that ablates (eliminates) its protein-protein interaction domain.

Describe the likely phenotypic outcome of this mutation and the molecular basis for this.

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Hox4 is a homeotic gene that controls the body plan of the embryo along ... View the full answer