17. Parents Jacob and Emma have had two children, Samuel and Matthew. Baby Samuel died at...

  

 

 

 

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17. Parents Jacob and Emma have had two children, Samuel and Matthew. Baby Samuel died at the age of nine days. When baby Matthew has trouble feeding, his parents take him in to the doctor. He is diagnosed with Maple Syrup Urine Disease (MSUD), a life- threatening condition in which the patient is not able to break down proteins from their food. As Matthew receives treatment, Jacob and Emma are referred to a genetic counselor. The genetic counselor collects information about their family. Neither of Jacob's parents were affected by MSUD. Jacob had one brother and three sisters. One of these sisters died shortly after birth. Similarly, neither of Emma's parents were affected by MSUD. Emma had four brothers, and two of these died shortly after birth. a. Given what you know about Jacob and Emma's family, construct a pedigree that includes all three generations. b. Based on the pedigree you constructed, is it likely that MSUD is caused by a dominant allele or recessive alleles? How can you tell? c. Of course, Jacob and Emma are concerned about their children. If they are to have more children, what would be the probability that they would have MSUD? 17. Parents Jacob and Emma have had two children, Samuel and Matthew. Baby Samuel died at the age of nine days. When baby Matthew has trouble feeding, his parents take him in to the doctor. He is diagnosed with Maple Syrup Urine Disease (MSUD), a life- threatening condition in which the patient is not able to break down proteins from their food. As Matthew receives treatment, Jacob and Emma are referred to a genetic counselor. The genetic counselor collects information about their family. Neither of Jacob's parents were affected by MSUD. Jacob had one brother and three sisters. One of these sisters died shortly after birth. Similarly, neither of Emma's parents were affected by MSUD. Emma had four brothers, and two of these died shortly after birth. a. Given what you know about Jacob and Emma's family, construct a pedigree that includes all three generations. b. Based on the pedigree you constructed, is it likely that MSUD is caused by a dominant allele or recessive alleles? How can you tell? c. Of course, Jacob and Emma are concerned about their children. If they are to have more children, what would be the probability that they would have MSUD?