a. Lamivudine 1 is an inhibitor of HIV reverse transcriptase and is used to combat HIV. i.
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Question:
a. Lamivudine 1 is an inhibitor of HIV reverse transcriptase and is used to combat HIV.
i. Apply Lipinski’s Rules to the structure of lamivudine.
ii. What does your Lipinski analysis tell you about the suitability of lamivudine as a drug? What are the limitations of this analysis?
iii. By comparing the structure of lamivudine 1 to cytosine deoxyribonucleotide 2, explain briefly how this drug might inhibit reverse transcriptase, and how doing so can fight HIV/ AIDS.
Related Book For
Biochemistry Concepts and Connections
ISBN: 978-0321839923
1st edition
Authors: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
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