A patient develops a blood infection with capsule$-$producing strain of E$.$ coli. Which of the following will be directly required to allow opsonization of the encapsulated E$.$ coli:

A$.$ release of TNF alpha, IL$-1,$ IL$-6,$ and IL$-8$

B$.$ toll$-$like receptor $($TLR$)$ binding of PAMPs

C$.$ formation of the C $5$ convertase

D$.$ binding of C $5$ a to the C $5$ a receptor $($C$5$aR$)$

E$.$ release of alpha interferon

F$.$ binding to host cell receptors

G$.$ all of the above apply

H$.$ none of the above apply