It is known that the reaction of halobenzenes with potassium starch (KNH2) in liquid ammonia generating aniline
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It is known that the reaction of halobenzenes with potassium starch (KNH2) in liquid ammonia generating aniline occurs by an elimination-addition mechanism, with the formation of an intermediate capable of reacting with dienes to form Diels-Alder products.
a) Formulate the SNAr mechanism for non-activated aromatic compounds, highlighting crucial reaction intermediates.
b) Keeping in mind the halogen electronegativity order (F> Cl> Br> I) and the halide exit facility as the starting group (I> Br> Cl> F), explain the order of reactivity Br> I> Cl >> F against SNAr by elimination-addition, based on the mechanism proposed in the previous item.
Related Book For
Introduction to Probability
ISBN: 978-0716771098
1st edition
Authors: Mark Daniel Ward, Ellen Gundlach
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