After administration of a single IV bolus dose of 500 mg of a drug to a...

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After administration of a single IV bolus dose of 500 mg of a drug to a healthy person, the pharmacokinetics of this drug followed a two-compartment model. The following parameters were obtained: A = 4.6 mg/L, B = 13.5 mg/L, a1/2 = 6 min and B1/2 = 90 min What is first-order elimination rate constant from the central compartment (kel or k10) in min-1? After administration of a single IV bolus dose of 500 mg of a drug to a healthy person, the pharmacokinetics of this drug followed a two-compartment model. The following parameters were obtained: A = 4.6 mg/L, B = 13.5 mg/L, a1/2 = 6 min and B1/2 = 90 min What is first-order elimination rate constant from the central compartment (kel or k10) in min-1?

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To determine the firstorder elimination rate constant from the central compartment kel or k10 in min... View the full answer