V.T. a 34-year-old woman, presents complaining of fatigue. difficulty concentrating, and a decline in memory She...

  

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V.T. a 34-year-old woman, presents complaining of fatigue. difficulty concentrating, and a decline in memory She also notes unexplained weight gain over the past six months, an abnormal loss of hair, and menstrual irregularities indluding menorrhagia. She states that she often feels chilled without a light sweater. even in warm weather Physical Exam • V.T. is 55" tall and weighs 142 lb. • Pulse rate is 58 bpm (normal 00-100 bpm) • blood pressure is 118/08. • She has a slightly putffy face and her skin was noticeabiy dry. • The thyroid is firm and bosselated to palpation with an estimated weight of 25g (normal 15-20g). • The deep tendon reflexes are normally contractive but show delayed relaxation. Lab Tests • The physician ordered a number of lab tests to further evaluate VT condition. Results are shown below Lab tests #1 Thyroid Function Tests Serum thyrotropin (TSH) Serum thyroxine (free T4) V.T's values Reference range 22 0 pUiml 4.1 ng di 06-55 pUml 40-12 ng/di 1 Based on the patient history, physical exam, and lab tests, does the patient have hypothyraidiam or hyperthyroidiam? Provide five lines of evidence from her history and or physical exam to support your answer In follow-up tests, the physician ordered anti-thyroid antibody testing and the following results were obtained: Lab tests #2 Anti-Thyroid Antibody test Anti-thyroglobulin antibody (anti-Tg) Anti-thyroid peroxcidase antibody (anti-TPO) V.T's values Positive (1:640) Positive (1:128) Normal Negative Negative 2. Based on V.T.'s workup, what is the specific name of her condition? 3. Research the pathophysiology of the disease. Explain the details of the disease at the cellular and organ level. 4. Examine the reaults of the serum TSH and free T4 tests. Explain why levels of TSH are high. 5. How is this condition typically treated? One month after beginning treatment, V.T.'s lab tests show a TSH value of 3.2 uU/ml. 6. Explain how V.T's treatment brought TSH levels into the normal range. V.T. a 34-year-old woman, presents complaining of fatigue. difficulty concentrating, and a decline in memory She also notes unexplained weight gain over the past six months, an abnormal loss of hair, and menstrual irregularities indluding menorrhagia. She states that she often feels chilled without a light sweater. even in warm weather Physical Exam • V.T. is 55" tall and weighs 142 lb. • Pulse rate is 58 bpm (normal 00-100 bpm) • blood pressure is 118/08. • She has a slightly putffy face and her skin was noticeabiy dry. • The thyroid is firm and bosselated to palpation with an estimated weight of 25g (normal 15-20g). • The deep tendon reflexes are normally contractive but show delayed relaxation. Lab Tests • The physician ordered a number of lab tests to further evaluate VT condition. Results are shown below Lab tests #1 Thyroid Function Tests Serum thyrotropin (TSH) Serum thyroxine (free T4) V.T's values Reference range 22 0 pUiml 4.1 ng di 06-55 pUml 40-12 ng/di 1 Based on the patient history, physical exam, and lab tests, does the patient have hypothyraidiam or hyperthyroidiam? Provide five lines of evidence from her history and or physical exam to support your answer In follow-up tests, the physician ordered anti-thyroid antibody testing and the following results were obtained: Lab tests #2 Anti-Thyroid Antibody test Anti-thyroglobulin antibody (anti-Tg) Anti-thyroid peroxcidase antibody (anti-TPO) V.T's values Positive (1:640) Positive (1:128) Normal Negative Negative 2. Based on V.T.'s workup, what is the specific name of her condition? 3. Research the pathophysiology of the disease. Explain the details of the disease at the cellular and organ level. 4. Examine the reaults of the serum TSH and free T4 tests. Explain why levels of TSH are high. 5. How is this condition typically treated? One month after beginning treatment, V.T.'s lab tests show a TSH value of 3.2 uU/ml. 6. Explain how V.T's treatment brought TSH levels into the normal range.