Question: Consider the drug patch shown below. The patch consists of a drug reservoir mounted on top of a gel diffusion barrier. A 3 c m
Consider the "drug patch" shown below. The patch consists of a drug reservoir mounted on top of a gel diffusion barrier. A patch has a diffusion barrier with a thickness of The diffusion barrier is in direct contact with the skin. The drug release vs time profile is shown below. The drug is only slightly soluble in the gel diffusion barrier, with a maximum solubility of at the top of the barrier. Other experiments show the drug is immediately absorbed into the bloodstream after exiting the patch ie it is instantly cleared
a State the boundary conditions for this system.
b Explain why this system can be modeled as steadystate.
c Solve the differential mass balance to find the concentration profile.
d Calculate the drug release rate, equivalent to and use Fick's Law to estimate the diffusion coefficient of the drug in the diffusion barrier.
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