Question: Consider the hypothetical serine protease below, which shows the specificity pockets. The S pocket has a glutamic acid in the bottom, the S pocket

Consider the hypothetical serine protease below, which shows the specificity pockets. The

Consider the hypothetical serine protease below, which shows the specificity pockets. The S pocket has a glutamic acid in the bottom, the S pocket is small and hydrophobic, and the S; pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. R3 Arg-lle-Val lle-Arg-Val Arg-Val-lle Val-Arg-lle Val-Ile-Arg lle-Val-Arg S S1 & Which of the following sequences would this protease cleave? I R S' The S pocket is small and hydrophobic. Consider the size of the amino acid side chain that could fit in this pocket. Is the side chain more likely to be hydrophobic (nonpolar) or polar? The S pocket has a negative charge. Consider the charge of the amino acid likely to interact with this pocket. The S pocket is deep and hydrophobic. Look for a bulky hydrophobic side chain for the corresponding amino acid.

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