Consider the hypothetical serine protease below, which shows the specificity pockets. The S pocket has a...
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Consider the hypothetical serine protease below, which shows the specificity pockets. The S₁ pocket has a glutamic acid in the bottom, the S₂ pocket is small and hydrophobic, and the S; pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. R3 Arg-lle-Val lle-Arg-Val Arg-Val-lle Val-Arg-lle Val-Ile-Arg lle-Val-Arg S₂ S1 & Which of the following sequences would this protease cleave? I R₁ S₁' The S₂ pocket is small and hydrophobic. Consider the size of the amino acid side chain that could fit in this pocket. Is the side chain more likely to be hydrophobic (nonpolar) or polar? The S₁ pocket has a negative charge. Consider the charge of the amino acid likely to interact with this pocket. The S₁ pocket is deep and hydrophobic. Look for a bulky hydrophobic side chain for the corresponding amino acid. Consider the hypothetical serine protease below, which shows the specificity pockets. The S₁ pocket has a glutamic acid in the bottom, the S₂ pocket is small and hydrophobic, and the S; pocket is deep and hydrophobic. Suggest an amino acid sequence that this protease would cleave. R3 Arg-lle-Val lle-Arg-Val Arg-Val-lle Val-Arg-lle Val-Ile-Arg lle-Val-Arg S₂ S1 & Which of the following sequences would this protease cleave? I R₁ S₁' The S₂ pocket is small and hydrophobic. Consider the size of the amino acid side chain that could fit in this pocket. Is the side chain more likely to be hydrophobic (nonpolar) or polar? The S₁ pocket has a negative charge. Consider the charge of the amino acid likely to interact with this pocket. The S₁ pocket is deep and hydrophobic. Look for a bulky hydrophobic side chain for the corresponding amino acid.
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