Glucogenic Substrates A common procedure for determining the effectiveness of compounds as precursors of glucose in...

Transcribed Image Text:

Glucogenic Substrates A common procedure for determining the effectiveness of compounds as precursors of glucose in mammals is to starve the animal until the liver glycogen stores are depleted and then administer the compound in question. A substrate that leads to a net increase in liver glyco- gen is termed glucogenic because it must first be converted to glucose 6-phosphate. Show by means of known enzymatic reactions which of the following substances are glucogenic: (a) Succinate, OOC-CH-CH-COO OH OH OH (b) Glycerol, CH-C-CH.2 H 0 (e) Acetyl-CoA, CH-C-S-C 0 -&-co CH-C-COO CH-CH-CH-COO (d) Pyruvate, (e) Butyrate, Glucogenic Substrates A common procedure for determining the effectiveness of compounds as precursors of glucose in mammals is to starve the animal until the liver glycogen stores are depleted and then administer the compound in question. A substrate that leads to a net increase in liver glyco- gen is termed glucogenic because it must first be converted to glucose 6-phosphate. Show by means of known enzymatic reactions which of the following substances are glucogenic: (a) Succinate, OOC-CH-CH-COO OH OH OH (b) Glycerol, CH-C-CH.2 H 0 (e) Acetyl-CoA, CH-C-S-C 0 -&-co CH-C-COO CH-CH-CH-COO (d) Pyruvate, (e) Butyrate,

Answer rating: 100% (QA)

The detailed ... View the full answer