In a recombinant protein expression process the host microorganism, Pichia pastoris needs to be separated from the
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In a recombinant protein expression process the host microorganism, Pichia pastoris needs to be separated from the culture supernatant after production. A pilot scale bioreactor with a working volume of 250 liters is used for this process and the final biomass concentration is 330 g/L. Considering the separation should be finished in 1 hour. If you wanted the reduce the duration of this separation process by 50% what would you change? Consider and mention the benefits and disadvantages of such a change.
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