Question: In an MTD tox study, a dog was given 40 mg/kg of drug substance after the 20 mg/kg dose. The 40 mg/kg resulted in emesis.

In an MTD tox study, a dog was given 40 mg/kg

In an MTD tox study, a dog was given 40 mg/kg of drug substance after the 20 mg/kg dose. The 40 mg/kg resulted in emesis. What is the MID? Three doses used in a 28 day tox study (using the above MTD tox Study) were: MTD dose, MTD dose/2 MTD dose/4 Equation: Aggregate dose = MTD dose + MTD dose/2 + MTD dose/4 What is the Aggregate Dose? Aggregate Dose = How much drug substance is required for a 28-day tox study with an overage of 1.1 using 20 dogs based on the Aggregate dose

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