In the blue box below, draw a generalized mechanistic model (using arrows to represent the flow of electrons) for how to produce an amide from a carbonyl-containing compound and an amine. Start with the reactants, draw the tetrahedral intermediate formed, and show formation of the product of the reaction. Be sure to label all general components of the reaction, including reactants, intermediates, products, leaving groups (LG), nucleophiles (Nuc^-), and electrophiles (E⁺). In the reactants of your mechanistic model, label areas of high and low electron density with either a partial positive (delta +) or partial negative (delta -) sign.

In the blue box below, draw a generalized mechanistic model (using arrows to represent the flow of electrons) for how to produce an amide from a carbonyl-containing compound and an amine. Start with the reactants, draw the tetrahedral intermediate formed, and show formation of the product of the reaction. Be sure to label all general components of the reaction, including reactants, intermediates, products, leaving groups (LG), nucleophiles (Nuc), and electrophiles (E+). In the reactants of your mechanistic model, label areas of high and low electron density with either a partial positive (delta + ) or partial negative (delta -) sign