Question: Mutli-step question for Schild Plot concept and application: a. Use the data below to calculate pA2 for AO7 from the U58 data. Start by calculating

Mutli-step question for Schild Plot concept and application:

a. Use the data below to calculate pA2 for AO7 from the U58 data. Start by calculating the dose ratios.

[U58] (M)	[AO7] needed for 50% response
no antagonist present	4.0E-09
5.00E-08	6.3E-09
2.00E-07	1.3E-08
2.50E-07	1.4E-08

b. Using your result above, determine the Kd for U58, being sure to specify which receptor subtype the Kd is for.

c. Use the data below for agonist (A) with a competitive antagonist (B) to produce a Schild plot and report the value of pA2. (All concentrations are in M.)

[A] for 50% biol effect [B]

7.50E-09 none

8.00E-09 1.00E-08

8.40E-09 1.80E-08

1.00E-08 5.00E-08

Step by Step Solution

There are 3 Steps involved in it

1 Expert Approved Answer

Step: 1 Unlock blur-text-image

Question Has Been Solved by an Expert!

Get step-by-step solutions from verified subject matter experts

Step: 2 Unlock

Step: 3 Unlock

Students Have Also Explored These Related Chemistry Questions!

Data Interpretation Practice Question: Lowacidine Schild Plot Histamine stimulates the release of hydrochloric acid from parietal cells in the stomach muscosa by binding to histamine ( H 2 )...

Can someone explain the breakdown of the answer? It says construct a Schild plot but most answers I've seen do not have a Schild plot attached and it's confusing how these values are derived 8....

Use the data below for agonist (A) with a competitive antagonist (B) to produce a Schild plot. Once the shield plot is found, find the pA2 value, and the Kd for the data. [A] for 50% biol effect [B]...

write a c++ code Note (4 points). All the following curves must be graphed in the time window of [ 0 13] (sec) by using ( mathrm{N}=2000 ) data points. Question #1-(a)_(3 points). Write a code and...

Question 7: Draw a correlation plot showing all pairwise associations among the following variables: "attend", "termGPA", "priGPA" and "ACT". Next, add the variables "final" ,"atndrte" and "hwrte" to...

Part 2: Population growth in a 3-compartment model (25 points) In this we section consider a 3-compartment model. The equations are provided, but you need to solve them, plot the results and consider...

This is a problem statement . Need the MATLAB code for all the specifications ( specify with number of question to which the code is written ) and comments please .Need as soon as possible . Assuming...

In this question, you will be presented with a graphic plot, and code that creates a graphic that doesnt quite accomplish the goal. Your objective is to modify the incorrect code until it creates the...

URGENT weite the c++ code and show the output Note (4 points). All the following curves must be graphed in the time window of [013] (sec) by using N=2000 data points. Question \#l-(a) (3 points),...

wirte a c++ code ans please show rhe output Note (4 points). All the following curves must be graphed in the time window of [013] (sec) by using N=2000 data points. Question \#l-(a) (3 points), Write...

Think about exceptionally good and bad salespeople you have encountered as a shopper. What qualities seem to differentiate them from others?

When Cyclohexanone is heated in the presence of a large amount of acetone cyanohydrin and a small amount of base, Cyclohexanone cyanohydrin and acetone arc formed. Propose amechanism. HO CN OH "OH +...

Question 2 ( Mandatory ) ( 1 0 points ) Alpha Corporation has a market value of $ 6 5 0 while Gamma Corporation has a market value of $ 1 , 1 0 0 . The two firms are merging and expect the combined...

Use Dijkstra's algorithm to find the shortest distance from a to f Create a table documenting the steps and actions of the algorithm.

For providing illustration in a report or proposal, when is a diagram a better choice than a photograph? [LO-3]

The ad agencies accounts include the following consumer- brands; Walmart, Southwest airlines, FedEx, Land Rover, and Krispy Kreme.

PetSmart allows pets and their humans to together stroll the aisles of its stores; the number one Specialty Retailer of pet supplies.