Question: Question 1. You are running reverse phase HPLC on two compounds (compound A and compound B). The mobile phase is 8:1 ammonium formate buffer:acetonitrile (pH

Question 1.

You are running reverse phase HPLC on two compounds (compound A and compound B). The mobile phase is 8:1 ammonium formate buffer:acetonitrile (pH = 4.5). Both compounds are chemically neutral. Compound A has a logP of 1.0 whereas compound B has a logP of 3.2. With the information provided which of the following would you predict to be true?

Question 1 options:

A)

Compound A will elute before Compound B.

B)

Compound B will elute before Compound A.

C)

It is not possible to say with the information given.

D)

Compound A and B will elute at the same time.

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